PUBLICATIONS
Publications from work supported by the CTT
Select a subject area to see a list of publications:
Pro-thrombotic Risk in Patients
Al-Obaidi MK, Philippou H, Stubbs PJ et al. Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes. Circulation 2000;101:372-377
Stubbs, P, Al-Obaidi MK, Conroy RM, et al. Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes. Circulation 2000;102:605-610
Stubbs PJ, Laycock J, Alaghband-Zadeh J et al. Circulating stress hormone and insulin concentration in acute coronary syndromes: identification of insulin resistance on admission. Clinical Science 1999;96:589-595
Stubbs PJ, Alaghband-Zadeh J, Laycock JF, et al. The prognostic significance of an index of insulin resistance on admission in non-diabetic patients with acute coronary syndromes. Heart 1999;82:443-447
Stubbs P, Seed M, Lane D,et al. Lipoprotein(a) as a risk predictor for cardiac mortality in patients with acute coronary syndromes. Eur Heart J 1998;19:1355-1364
Stubbs P, Seed M, Moseley D et al. A prospective study of the role of lipoprotein(a) in the pathogenesis of unstable angina. Eur Heart J 1997;18:603-607
Noble MIM. Overview: Thrombosis as a unitary hypothesis of cardiovascular risk. J Cardiovasc Risk 1995;2:177-179
Stubbs PJ, Mulrooney BD, Collinson PO, Fowler PBS, Noble MIM. The relationship between serum lipids and serum thyrotrophin in women with coronary artery disease. Eur Heart J 1994;15:468-471
Dubrey S, Reavely DR, Seed M, et al. Risk factors for ischaemic heart disease in insulin dependent diabetes: a study of identical twins. Diabetes 1994;43:831-835
Physiology & Pathophysiology
Menys V et al. Platelet 5-hydroxytryptamine is decreased in a preliminary group of depressed patients receiving the 5-hydroxytrptamine re-uptake inhibiting drug fluoxetine. Clin Sci 1996;91:87-92
Menys VC et al. Impaired platelet aggregation after cardiopulmonary bypass in man: enhancement of collagen-induced aggregation in whole blood and plasma by adrenaline ex vivo. Clin Sci 1995;88:269-275
Menys VC et al. Macroaggregation of platelets in plasma, as distinct from microaggregation in whole blood (and plasma), as determined by optical aggregometry and platelet counting respectively, is specifically impaired following cardopulmonary bypass in man. Thromb Haemost 1994:72:511-518
Menys, V. Collagen induced human aggregation: serotonin receptor antagonism retards aggregate growth in vitro. Cardiovasc Res 1993;27:1916-1919
Noble MIM, Drake-Holland AJ. The involvement of serotonin in the formation of thrombi at critical coronary artery stenoses in humans. Cor Art Dis 1990;1:675-679
Noble MIM, Drake-Holland AJ. Evidence for a role of serotonin in initiation of coronary arterial thrombosis. Clin Physiol Biochem 1990;8(suppl 3):50-55
Novel Anti-thrombotic Therapies
Belcher PR, Drake-Holland AJ, Noble MIM. The anti-platelet drug target in athersclerotic diseases. Cardiovasc & Haematol Disorders - Drug Targets 2006;6:43-55
Belcher, PR, Drake-Holland, AJ. Serotonin reuptake inhibitors and cardiovascular disease. Coronary Health Care 2001;5:141-147
Noble MIM, Drake-Holland AJ. Mini-review: The role of serotonin 5HT2 receptor antagonism in the control of coronary artery disease. QJ Med 1994;87:11-16
Secondary Effect of Coronary Thrombosis
Chaudhry MA, Belcher PR, Day SP, Muriithi EW, Wheatley DJ. Erythrocyte-containing versus crystalloid cardioplegia in the rat: effects on myocardial capillaries. Ann Thorac Surg 2003;75:890-898
Al-Obaidi MK, Stubbs PJ, Collinson P et al. Elevated homocysteine levels are associated with increased ischemic myocardial injury in acute coronary syndromes. J Am Coll Cardiol 2000;36:1217-1222
Noble MIM. Can negative results of protein markers of myocardial damage justify of acute chest pain patients after a few hours in hospital? Eur Heart J 1999;20:925-927
Pathi VL, Wheatley DJ, McPhaden AR, et al. The effects of cardioplegic arrest and reperfusion on the microvasculature of the heart. Eur J Cardio-thorac Surg 1997;11:350-7
Belcher PR, Pathi VL, Wheatley DJ. Myocardial capillaries following crystalloid cardioplegic arrest and reperfusion. Cardiovasc Eng 1997;2:191-7
Stubbs P Collinson P, Moseley D et al. Prognostic significance of admission Troponin T concentrations in patients with myocardial infarction. Circulation 1996;94:1291-1297
Genetics of Thrombosis
Humphries SE, Whittall R, Hubbard C, et al. The utility of DNA-based testing in patients with familial hypercholesterolaemia in the UK. Atherosclerosis 2005;182,:85-?
Konstantoulas CJ, Cooper J, Warnock G, et al. A combination of two common thrombomodulin gene variants influence risk of coronary heart disease. Atherosclerosis 2004;177(1):97-104
Konstantoulas CJ, Hawe E, Saut N, et al. Common variants in the thrombomodulin gene form a risk for myocardial infarction in the North of Europe (HIFMECH study). Thromb & Haemostas 2004;91:628-630
Ireland, H, Miller, G, Webb, K, Cooper, J, Humphries, S.E. The Factor VII ativating protease G511E (Marburg) variant and cardiovascular risk. Thromb & Haemostas 2004;92:986-992
Neil HAW, Seagroatt V, Betteridge DJ, et al. Establishes and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia. Heart 2004;90:1431-1437
Neil HAW, Huxley RR, Hawkins MM, et al. Comparison of the risk of fatal heart disease in treated xanthomatous and non-xanthomatous heterozygous familial hypercholesterolaemia: a prospective registry study. Atherosclerosis 2003;170:73-78
J Chambers, H Ireland, E Thompson, et al. The methylenetetrahydrofolate reductase 677 C->T mutation coronary heart disease risk in UK Indian Asians. Atherosclerosis, Thrombo & Vasc Biol 2000
G Kunz, H Ireland, PJ Stubbs, et al. Identification and characterisation of a thrombomodulin gene mutation coding for an elongated protein with reduced expression in a kindred with myocardial infarction. Blood 2000;95:569-576
Warner D, Catto A, Kunz G, et al. The thrombomodulin gene mutation G(127)->A (Ala25Thr) and cerebrovascular disease. Cerebrovasc Dis 2000;10(5):359-63
Doggen CJM, Kunz G, Rosendaal FR, et al. A mutation in the thrombomodulin gene 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men.Thromb Haemost 1998;80:743-8
Ireland H, Kunz G, Kyriakoulis K, et al. Thrombomodulin gene mutations associated with myocardial infarction. Circulation 1997;96:15-18
Ireland H, Kyriakoulis K, Kunz G, Lane DA: Directed search for thrombmodulin gene mutations. Haemostasis 1996;26:227-232
General
Markos F, Ruane O’Hara T, Snow HM, et al. Dilatation of the femoral vascular bed does not cuase retrograde relaxation of the iliac artery in the anaethetised pig. Acta Physiolog 2008;194:207-213
Noble MIM, Drake-Holland AJ, Vink, H. Hypothesis: arterial glycocalyx dysfunction in the first step in the atherothrombotic process.QJ Med 2008;101:513-518
Alders DJC, Cornelussen RN, Prinzen FW, et al. Regional sympathetic denervation affects the relation between local canine myocardial blood flow and oxygen consumption. Exp Physiol 2007;92:541-548
Rimoldi OE, Drake-Holland AJ, Noble MIM, Camici PG. Resting and hyperemic myocardial blood flow in regionally denervated canine hearts: an in vivo study with positron emission tomography. Eur J Nucl Med & Mol Imaging 2007; 34:197-205
Kelly R, T Ruane-O’Hora, MIM Noble, et al. Differential inhibition by hyperglycaemia of shear stress, but not acetylcholine mediated dilatation in the iliac artery of the anaesthetized pig. J Physiol 2006;573:133-145
Drake-Holland AJ, Etherington PJE, Winlove PR, Noble MIM. Soluble indicators may give false values for regional myocardial blood flow in the presence of coronary artery occlusion. Res Cardovasc Sci 2006 e-pub Wed 26th July
Drake-Holland AJ, Etherington PJE, Winlove CP, Belcher PR, Noble MIM. Preconditioning is associated with improved tissue nutrient delivery and increased tissue oxygen extraction in canine myocardium. Res Cardovasc Sci 2006 e-pub Tues 26 Sep
Borg CM, le Roux CW, Ghatei MA, et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Brit J Surg, Jan 3, 2006
le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatic surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006;243:108-114
le Roux CW, Batterham RL, Aylwin SJ, et al. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 2006;143:3-8
Serotonin reuptake inhibitors and cardiovascular disease. Belcher PR, Drake-Holland AJ, Noble MIM. Vasc Dis Preven 2005;2:67-76
le Roux, CW, Neary, NM, Halsey, TJ, Small, CJ, Martinez-Isla, AM, Ghatei, MA, Theodorou, NA, Bloom, SR. Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrin Metab, 2005;90: 4521-4524
le Roux CW, Patterson M, Vincent RP, et al. Postprandial plasma ghrelin is suppressed proportional to meal caloric content in normal-weight but not obese subjects. J Clin Endocrin Metab 2005;90:1068-1071
le Roux CW, Ghatei MA, Gibbs JS, Bloom, SR. The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Heart 2005;91:241-242
Huxley RR, Hawkins MH, Humphries SE, Karpe, F, Neil, HAW. Risk of fatal stroke in patients with treated familial hypercholesterolemia: A prospective registry study. Stroke 2003;34:22-27