PUBLICATIONS
Publications from work supported by the CTT
The Coronary Thrombosis Trust has launched a new free electronic journal called Resources In Cardiovascular Science and is open for the submission of papers.
Select a subject area to see a list of publications:
General
Borg, CM, le Roux, CW, Ghatei, MA, Bloom, SR, Patel, AG, Aylwin, SJ. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. British Journal of Surgery, Jan 3, 2006.
le Roux, CW, Aylwin, SJ, Batterham, RL, Borg, CM, Coyle, F, Prasad, V, Shurey, S, Ghatei, MA, Bloom, SR. Gut hormone profiles following bariatic surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Annals of Surgery, 243, 108-114, 2006.
le Roux, CW, Batterham, RL, Aylwin, SJ, Patterson, M, Borg, CM, Wynne KJ, Kent, A, Vincent, RP, Gardiner, J, Ghatei, MA, Bloom, SR. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147, 3-8, 2006.
le Roux, CW, Neary, NM, Halsey, TJ, Small, CJ, Martinez-Isla, AM, Ghatei, MA, Theodorou, NA, Bloom, SR. Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. Journal of Clinical Endocrinology and Metabolism, 90, 4521-4524, 2005.
le Roux, CW, Patterson, M, Vincent, RP, Hunt, C, Ghatei, MA, Bloom, SR. Postprandial plasma ghrelin is suppressed proportional to meal caloris content in normal-weight but not obese subjects. Journal of Clinical Endocrinology and Metabolism, 90, 1068-1071, 2005.
le Roux, CW, Ghatei, MA, Gibbs, JS, Bloom, SR. The putative satiety hotmone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Heart 91, 241-242, 2005.
Huxley, RR, Hawkins, MH, Humphries, SE, Karpe, F, Neil, HAW. Risk of fatal stroke in patients with treated familial hypercholesterolemia: A prospective registry study. Stroke, 34, 22-27, 2003
Weighing the Benefits and Risks of Aspirin in Primary and
Secondary Prevention of Ischemic Vascular Events. A review of
2 meta-analyses
evaluating the effect of broader application of aspirin therapy
and its effect on patient outcomes for both primary and secondary
prevention. Cardiovasc Rev Rep 25(2) 2004.
High Prevalence of Metabolic Syndrome Among Young Women With
Nonfatal Myocardial Infarction. Prior studies of young women with
MIs have found a high prevalence of obesity, diabetes, and hypertriglyceridemia,
all of which are components of the metabolic syndrome (MetS). However,
neither other components of the MetS nor other recently recognized
thrombophilic factors or markers for coronary disease have been
systematically evaluated in such patients. J Womens Health 13(2)
2004
Obesity as the Core of the Metabolic Syndrome and the Management
of Coronary Heart Disease. This review examines the contribution
of excess bodyweight to increased CHD risk factors, and discusses
guideline recommendations and the potential for treatment strategies
to optimally improve a patient's CHD risk factor profile. Curr
Med Res Opin 20(3) 2004
Journal Article. Lack of Aspirin Effect: Aspirin Resistance or
Resistance to Taking Aspirin?
Serotonin reuptake inhibitors and cardiovascular disease. Belcher PR, Drake-Holland AJ, Noble MIM. Vascular Disease Prevention. 2005;2:67-76
The antiplatelet drug target in atherosclerotic diseases. Belcher PR, Drake-Holland AJ, Noble MIM. Cardiovascular & Haematological Disorders – Drug Targets 2006. Mar; 6(1):43-55. PMID: 16724935 [PubMed - in process]
The beat-to-beat decay of cardiac contractility from highly potentiated levels is bi-exponential. Noble MIM, Arlock AP, Wohlfart B, Drake-Holland AJ. Journal of Biomechanics2006, 39:2657-2664
Effect of hyperglycaemia on endothelial dependent dilatation in the iliac artery of the anaesthetized pig. R Kelly, T Ruane- O’Hora, MIM Noble, AJ Drake-Holland, HM Snow. Journal of Physiology. (2006) 573:133-145)
A Method of Assessing the Myocardial Capillary Bed in Patients. PR Belcher, MIM Noble, CP Winlove, AJ Drake-Holland, JD Laird, CKMNoble. Resources in Cardiovascular Science (2006) Epub Thursday 1st June (14 pages).
A Method of Non-Parametric Comparison of Two Correlation Relationships. Mark IM Noble, Cardiovascular Science (2006) Epub. Wednesday 31st May (5 pages).
Soluble indicators may give false values for regional myocardial blood flow in the presence of coronary artery occlusion. Drake-Holland, AJ, Etherington, PJE, Winlove, PR, Noble, M.I.M. Resources in Cardiovascular Science (2006) Epub Wednesday 26th July (7 pages).
Antidromic signalling does not contribute to the vasodilatory response of the iliac artery to acetylcholine, in the anaesthetized pig. RKelly, T Ruane-O’Hora, MIM Noble, and HM Snow. Resources in Cardiovascular Science. (2006) Epub Thursday 22nd June.
Preconditioning is associated with improved tissue nutrient delivery and increased tissue oxygen extraction in canine myocardium. Drake-Holland, A.J, Etherington, P.J.E, Winlove, C.P, Belcher, P.R, Noble, M.I.M. Resources in Cardiovascular Science, Tuesday 26 September, 2006, Epub 9 pages.
Regional sympathetic denervation affects the relation between local canine myocardial blood flow and oxygen consumption. Alders, DJC, Cornelussen, RN, Prinzen, FW, Specht, PAC, Noble, MIM, Drake-Holland, AJ, de Kanter, FJJ, and van Beek, JHGM. Experimental Physiology 2007, 92:541-548.
Resting and hyperemic myocardial blood flow in regionally denervated canine hearts: an in vivo study with positron emission tomography. Rimoldi, O.E, 1, Drake-Holland, A.J, Noble, M.I.M, and Camici, P.G. European Journal of Nuclear Medicine and Molecular Imaging (2007) 34:197-205
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Genetics of thrombosis
Humphries, SE, Whittall, R, Hubbard, C, Cooper, JA, Soutar, A, Naoumova, R, Thompson, GR, Seed, M, Durrington, PN, Miller, JP, Betteridge, DJB, Neil, A. The utility of DNA-based testing in patients with familial hypercholesterolaemia in the UK. Atherosclerosis 182, 85, 2005.
Neil, HAW, Huxley, RR, Hawkins, MM, Durrington, PN, Betteridge, DJ, Humphries, SE. Comparison of the risk of fatal heart disease in treated xanthomatous and non-xanthomatous heterizygous familial hypercholesterolaemia: a prospective registry study. Atherosclerosis 170, 73-78, 2003
Neil, HAW, Seagroatt, V, Betteridge, DJ, Cooper, MB, Durrington, PN, Miller, JP, Seed, M, Naoumova, RP, Thompson, GR, Huxley, R, Humphries, SE. Establishes and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia. Heart 90, 1431-1437, 2004
Ireland H, Kyriakoulis K, Kunz G, Lane DA: Directed search for
thrombmodulin gene mutations. Haemostasis 26:227-232, 1996
Ireland H, Kunz G, Kyriakoulis K, Stubbs PJ, Lane DA. Thrombomodulin
gene mutations associated with myocardial infarction. Circulation
96:15-18, 1997
Doggen CJM, Kunz G, Rosendaal FR, Lane DA, Vos HL, Stubbs
PJ, Manger Cats V, Ireland H. A mutation in the thrombomodulin
gene 127G to A coding for Ala25Thr, and the risk of myocardial
infarction in men.Thromb Haemost 80: 743-8, 1998
J Chambers, H Ireland, E Thompson, P Reilly, O Obeid, H Refsum,
P Ueland, D Lane, J Kooner. The methylenetetrahydrofolate
reductase 677 C->T mutation coronary heart disease risk
in UK Indian Asians. Atherosclerosis, Thrombosis and Vascular
Biology 2000
G Kunz, H Ireland, PJ Stubbs, M Kahan, GC Coulton, DA Lane. Identification
and characterisation of a thrombomodulin gene mutation
coding for an elongated protein with reduced expression
in a kindred with
myocardial infarction. Blood 95 569-576, 2000.
Warner D, Catto A, Kunz G, Ireland H, Grant PJ, Lane DA.
The thrombomodulin gene mutation G(127)->A (Ala25Thr) and cerebrovascular disease.
Cerebrovascular Disease 10 (5): 359-63, 2000
Konstantoulas, CJ, Cooper, J, Warnock, G, Miller, GJ, Humphries, SE, Ireland, H. (2004a). A combination of two common thrombomodulin gene variants influence risk of coronary heart disease. Atherosclerosis 177(1) 97-104.
Konstantoulas, CJ, Hawe, E, Saut, N, Yudkin, JS, Diminno, G, Margaglione, M Hamsten, A, Humphries, SE, Juhan-Vague, I, Ireland, H. (2004b). Common variants in the thrombomodulin gene form a risk for myocardial infarction in the North of Europe (HIFMECH study). Thrombosis & Haemostasis 91, 628-630
Ireland, H, Miller, G, Webb, K, Cooper, J, Humphries, S.E. The Factor VII ativating protease G511E (Marburg) variant and cardiovascular risk. Thrombosis and Haaemostasis 2004, 92:986-992
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Physiology and pathophysiology of thrombocytes (platelets)
Noble MIM, Drake-Holland AJ. The involvement of serotonin
in the formation of thrombi at critical coronary artery stenoses
in humans.
Coronary Artery Disease1990;1:675-679
Noble MIM, Drake-Holland AJ Evidence for a role of serotonin
in initiation of coronary arterial thrombosis.. Clin Physiol
Biochem
1990;8(suppl 3):50-55
Menys, V. Collagen induced human aggregation: serotonin
recdeptor antagonism retards aggregate growth in vitro.
Cardiovascular
Research 1993;27:1916-1919
Menys VC Macroaggregation of platelets in plasma, as
distinct from microaggregation in whole blood (and
plasma), as
determined by
optical aggregometry and platelet counting respectively,
is specifically impaired following cardopulmonary bypass
in man.
Thromb Haemost
1994:72:511-518
Menys VC. Impaired platelet aggregation after cardiopulmonary
bypass in man: enhancement of collagen-induced aggregation
in whole blood
and plasma by adrenaline ex vivo.. Clinical Science
1995;88:269-275
Menys V. Platelet 5-hydroxytryptamine is decreased
in a preliminary group of depressed patients receiving
the
5-hydroxytrptamine
re-uptake inhibiting drug fluoxetine. Clin Sci 1996;91:87-92
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Pro-thrombotic risk factors in patients
Stubbs P. The relationship between serum lipids and serum
thyrotrophin in women with coronary artery disease., Eur
Heart J 1994;15:468-471
Dubrey S. Risk factors for ischaemic heart disease
in insulin dependent diabetes: a study of identical twins. Diabetes
1994;43:831-835
Noble MIM Overview: Thrombosis as a unitary hypothesis
of cardiovascular risk. J Cardiovasc Risk 2:177-179
Stubbs P. A prospective study of the role of lipoprotein(a)
in the pathogenesis of unstable angina. Eur Heart
J 1997;18:603-607
Stubbs P. Lipoprotein(a) as a risk predictor for
cardiac mortality in patients with acute coronary
syndromes.
Eur Heart J 1998;19:1355-1364
Stubbs PJ. Circulating stress hormone and insulin
concentration in acute coronary syndromes: identification
of insulin
resistance on admission.
Clinical Science
1999;96:589-595
Stubbs PJ. The prognostic significance of an index of insulin
resistance on admission in non-diabetic patients with acute
coronary syndromes.
Heart 1999;82:443-447
Al-Obaidi. Relationships between homocysteine, factor VIIa,
and thrombin generation in acute coronary syndromes.
Circulation 2000;101:372-377
Stubbs, P. Effect of plasma homocysteine concentration on
early and late events in patients with acute coronary syndromes.
Circulation2000;102:605-610
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Secondary effects of coronary thrombosis
Stubbs P, Prognostic significance of admission Troponin T concentrations
in patients with myocardial infarction. Circulation 1996;94:1291-1297
Noble MIM. Can negative results of protein markers of myocardial
damage justify of acute chest pain patients after a few hours in
hospital?
European Heart
Journal 1999;20:925-927
Al-Obaidi MK. Elevated homocysteine levels are associated with
increased ischemic myocardial injury in acute coronary syndromes.
Journal of
the American College
of Cardiology 2000;36:1217-1222
Pathi VL, Wheatley DJ, McPhaden AR, Belcher PR, Morrison JN, Fenner JW, Martin W, McQuiston AM. The effects of cardioplegic arrest and reperfusion on the microvasculature of the heart. Eur J Cardio-thorac Surg 1997;11:350-7
Belcher PR, Pathi VL, Wheatley DJ. Myocardial capillaries following crystalloid cardioplegic arrest and reperfusion. Cardiovasc Eng 1997;2:191-7
Chaudhry MA, Belcher PR, Day SP, Muriithi EW, Wheatley DJ. Erythrocyte-containing versus crystalloid cardioplegia in the rat: effects on myocardial capillaries. Ann Thorac Surg 2003;75:890-8.
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Novel anti-thrombotic therapies
Noble MIM, Drake-Holland AJ. Mini-review: The role of serotonin
5HT2 receptor antagonism in the control of coronary artery disease.
QJ
Med 1994;87:11-16
Belcher, PR, Drake-Holland, AJ. Serotonin reuptake inhibitors
and and cardiovascular disease.
Improved Clinical Outcomes With Abciximab Therapy in Acute Myocardial
Infarction: A Systematic Overview of Randomized Clinical Trials.
Can the results of earlier trials demonstrating the efficacy of
the glycoprotein IIb/IIIa inhibitor abciximab in improving clinical
and angiographic outcomes be generalized to a broader patient population?
Am Heart J 147(3):457-462 2004.
Bioequivalence of Ximelagatran, an Oral Direct Thrombin Inhibitor,
as Whole or Crushed Tablets or Dissolved Formulation. The present
study showed that the pharmacokinetics of melagatran were not significantly
altered whether ximelagatran was given orally as a crushed tablet
mixed with applesauce or dissolved in water. Curr Med Res Opin
20(3) 2004.
Low-Molecular-Weight Heparins and Glycoprotein IIb/IIIa Antagonists
in Acute Coronary Syndromes. Current antithrombotic therapy for
the medical and invasive management of patients with acute coronary
syndromes (ACS) is far from optimal; patients remain at significant
risk of death or recurrent ischemic events despite receiving standard
treatment with unfractionated heparin (UFH) plus aspirin. J Invasive
Cardiol 16(3) 2004.
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Other research news
An article in the January 2003 New
Scientist (p-36-39)
reminds people that half the sufferers from heart attacks due
to coronary heart disease (CHD) have normal cholesterol levels
in
the blood. There
are more fundamental
things going on in CHD than problems from raised cholesterol – see
atherosclerosis and lipids in our questions and answers section.
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